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Die Absorption von oral eingenommenem Glutathion ist jedoch begrenzt, da es im Darm und Leber schnell abgebaut wird

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Marked redox changes in hepatocytes, by using oxidants or GSH depletion agents, cause necrosis, whereas modest redox changes sensitize hepatocytes to tumor necrosis factor (TNF)-induced apoptosis by inhibiting the expression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)-dependent survival genes [44]